[A18-55] Ingenol mebutate (actinic keratosis) - Benefit assessment according to §35a Social Code Book V

Last updated 03.12.2018

Project no.:

Commission awarded on 03.09.2018 by the Federal Joint Committee (G-BA).

Report type:
Dossier assessment

Commission completed

Drug Assessment

Application field:
Skin and hair


Patients with non-hyperkeratotic, non-hypertrophic actinic keratosis

Result of dossier assessment:

Actinic keratosis on face or scalp: hint of non-quantifiable (at most considerable) added benefit; on trunk or extremeties: added benefit not proven


After completion of the assessment by IQWiG the Federal Joint Committee (G-BA) conducts a commenting procedure. This may provide supplementary information and as a result lead to a modified benefit assessment. Further information and the decision on the early benefit assessment can be found on the relevant page of the G-BA website.


AMNOG as a learning system: New study on ingenol mebutate in actinic keratosis shows added benefit

Advantage over diclofenac in complete clearance of visible lesions / unclear sustainability of treatment effect

Accompanying information

Further information for consumers and patients is provided on IQWiG's health information website www.informedhealth.org.


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