Responder analysis thresholds for complex scales in benefit assessments – the 15% approach

Report documents

1. Extract of the working paper

   Responder analysis thresholds for complex scales in benefit assessments – the 15% approach

   published on

   11.08.2026

   Document type

   PDF document, 62 kB, DE, not accessible

   Download file : Extract of the working paper (PDF document, 62 kB, DE, not accessible)
2. Working paper

   Responder analysis thresholds for complex scales in benefit assessments – the 15% approach

   published on

   11.08.2026

   Document type

   PDF document, 507 kB, EN, not accessible

   DOI-Link

   https://doi.org/10.60584/GA25-04_en

   Download file : Working paper (PDF document, 507 kB, EN, not accessible)

Project details

Project no.

GA25-04

Report type

Working paper

Status

Commission completed

Department/Division

Drug Assessment

Note

In 2020, IQWiG published a new procedure for determining relevance thresholds for responder analyses of complex scales, in particular patient-reported outcomes (PROs), for the first time and has since applied this procedure (15% threshold). The aim of this general commission is to bring together the methodological principles and definitions published in various places regarding the “15% threshold” in a single document and, alongside the European health technology assessment, to make them accessible to a wider readership. In addition, more detailed information on the approach and the empirical basis used at the time is provided.

DOI

https://doi.org/10.60584/GA25-04_en